Melbourne Renegades 169 for 7 (Matthews 46, Hancock 4-20) beat Brisbane Heat 167 for 9 (Harris 65, Coyte 3-26) by two runs
Matthews was earlier due a winning score and delivered his best and most influential innings of the WBBL season, scoring 46 off 28 balls to help Renegades score 169 for 7.
Matthews took Georgia Redmayne’s first wicket and two deft catches before her heroics in the final over to restrict the Heat to 167 for 9.
With the bat, Matthews hit shots all over the ground. She looked ominous in the final overs until she was bowled by seamer Hancock, who finished with career-best figures of 4 for 20.
The Renegades were 134 for 2 in the 16th over before Hancock and part-time Harris got them back. Harris went 2 for 16 with his side effect.
The defeat could be costly for the Heat, who remain in third position in the WBBL table with 14 points, two behind the leader Perth Scorchers.